application of anti-emetics in a gel formulation
provides a rapid onset and offers an effective
alternative to oral administration. Oral surgeons have
found this formulation to be particularly useful.
Promethazine is commonly
compounded for topical or transdermal application to
treat nausea, vomiting, and vertigo, but this
preparation may be used as an antiemetic for cases
ranging from chemotherapy to motion sickness. The dose
is typically 25mg for adults, and the dose is decreased
for children. The gel is applied to an area of soft
skin, such as the inside of the wrist or arm, the side
of the torso, or the inside of the thigh. For children,
the gel is often applied to the inside of one wrist, and
then the wrists are rubbed together.
US Pharmacist, August 1999; 74-5
Other dosage forms
include suppositories and lollipops.